RNS Number : 9527F
Hemogenyx Pharmaceuticals PLC
26 February 2018


The information contained within this announcement is deemed to constitute inside information as stipulated under the Market Abuse Regulation (EU) No. 596/2014. Upon the publication of this announcement, this inside information is now considered to be in the public domain.


Hemogenyx Pharmaceuticals Plc

("Hemogenyx" or the "Company")


Statement re. Share Price Movement


Lead candidate shown to be effective in treatment of Leukemia


Hemogenyx Pharmaceuticals Plc (LSE: HEMO), the biotechnology company developing novel therapies to transform bone marrow, or blood stem cell, transplantation for the treatment of blood diseases, notes the recent share movement in the Company's share price in reaction to a premature disclosure which the company regrets and is not in accordance with the Company's policies on the release of information.


The Company can confirm that it has filed a provisional patent application relating to the Company's development of a new type of humanised mice with a chimeric mouse-human blood system that can be used to advance product development, as well as for other disease modelling and drug development.


First data results have shown that CDX bi-specific antibodies are capable of attacking and eliminating the blood cancer Acute Myelogenous Leukemia  (AML) in vitro. Using these new humanised mice the Company is confident that it should be able to demonstrate that its lead product, CDX bi-specific antibodies, are effective in the treatment of (AML). Use of the humanised mouse model should facilitate developing and progressing the CDX bi-specific antibodies into human trials, in line with the Company's development timeline.


AML affected about one million people globally in 2015 and resulted in 147,000 deaths. AML accounts for roughly 1.8% of cancer deaths in the United States with about 20,000 new cases diagnosed in the US and 18,000 cases in Europe every year.


Despite numerous advances in understanding of the biology and pathogenesis of AML, standard treatments remain unsatisfactory and initial treatment relies on intensive chemotherapy. Current transplantation treatments for patients with chemosensitive forms of the disease have only a 30% success rate, but many, often older, patients will not be healthy enough even to undergo such treatments. CDX bi-specific antibodies, will redirect a patient's own immune cells to eliminate both AML and blood stem cells preparing a patient with relapsed/refractory AML for bone marrow transplantation. Directors believe that this product could replace traditional methods of treatment of relapsed/refractory AML and conditioning such as chemotherapy and radiation.


Dr Vladislav Sandler, CEO & Co-Founder of Hemogenyx, commented: "We are hugely excited by the first solid data that we've received testing the efficacy of CDX antibodies against Acute Myelogenous Leukemia. The results which show that they can attack and eliminate AML cells is a true breakthrough and a significant development in our process of developing CDX to become a universally available conditioning product for patients undergoing bone marrow transplants as a treatment for serious blood diseases.


"In addition the new type of humanised mice opens the door to extending our work into other disease models and specific drug development which we expect to be of great interest to large biopharmaceutical companies and could form the basis of a number of significant future collaborations."




Hemogenyx Pharmaceuticals Limited


Dr Vladislav Sandler, Chief Executive Officer & Co-Founder

Via Walbrook PR

Dr Robin Campbell, Chairman

Optiva Securities Ltd

Tel: +44 (0)20 3137 1902

Christian Dennis 

Shard Capital Partners LLP

Tel: +44 (0)20 7186 9950

Damon Heath, Erik Woolgar

Peterhouse Corporate Finance Limited

Tel: +44 (0)20 7469 0930

Lucy Williams/Duncan Vasey

Walbrook PR (UK Media & Investor Relations)

Tel: +44 (0)20 7933 8780 or [email protected]

Paul McManus

Mob: +44 (0)7980 541 893

US Media enquiries

Lowell Goodman

Tel: +1 (323) 646-3249 or [email protected]


About Hemogenyx Pharmaceuticals Plc

Hemogenyx Pharmaceuticals Plc is a publicly traded company (LSE: HEMO) headquartered in London, with its wholly owned U.S. operating subsidiary, HemoGenyx LLC, located in its state-of-the-art research facility in Brooklyn, New York.


HemoGenyx is a preclinical-stage biopharmaceutical company focused on the discovery, development and commercialization of novel therapies and treatments for blood diseases such as leukemia and lymphoma. The company's leading technologies aim to change the way in which bone marrow/hematopoietic stem cell (BM/HSC) transplants are performed and improve their efficacy. HemoGenyx's two distinct and complementary products include an immunotherapy product for patient conditioning-the CDX bi-specific antibody-and a cell therapy product for BM/HSC transplantation-the HuPHEC. Each of these products holds the potential to revolutionize the way BM/HSC transplants are being performed, offering solutions that mitigate the dangers and limitations associated with the current standard of care.


For more information, visit www.hemogenyx.com.


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